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Ontologies are a representation of domain knowledge using defined concepts and the relationships between those concepts in a manner understandable to both humans and machines. However, this knowledge representation usually expresses a narrow, ideal situation, which might not reflect real-world complexities. Contextualization of the role concept (hereafter referred to as role) and role modelling provides a structured and modular way to capture these real-world complexities. In order to model how different regulatory contexts can affect the definition of the active moiety role, the general pattern for contextualized roles as shown in diagram 1 is applied to the examples for Amlodipine and Aripiprazole below.
substance constituency - constituency that defines some substance based on its relationship(s) to some other substance (ingredient) or moiety, potentially in some amount, in some context
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Diagram 1: General pattern for contextualized roles.
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